Griffonia simplicifolia is a West African plant known primarily for its seeds, which are rich in 5-Hydroxytryptophan (5-HTP), a precursor of the neurotransmitter serotonin. This member of the Fabaceae family grows as a climbing woody shrub, thriving in the tropical regions of West Africa. Its nutraceutical use is mainly focused on improving brain activity. Griffonia simplicifolia’s importance extends to traditional African medicine, where various parts of the plant were used for their medicinal properties.